Structure−Activity Relationships in Toll-like Receptor-2 Agonistic Diacylthioglycerol Lipopeptides
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چکیده
منابع مشابه
Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures.
The self-assembled structure of toll-like receptor agonist lipopeptides containing the CSK4 peptide sequence is examined in aqueous solution. A remarkable dependence of morphology on the number of attached hexadecyl lipid chains is demonstrated, with spherical micelle structures for mono- and di-lipidated structures observed, but flexible wormlike micelles for the homologue containing three lip...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2010
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm901839g